Kaitocephalin is a non-selective ionotropic glutamate receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate. It is produced by the fungus Eupenicillium shearii. Although similar molecules have been produced synthetically, kaitocephalin is the only known naturally occurring glutamate receptor antagonist. There is some evidence that kaitocephalin can protect the brain and central nervous system, so it is said to have neuroprotective properties. Kaitocephalin protects neurons by inhibiting excitotoxicity, a mechanism which causes cell death by overloading neurons with glutamate. Because of this, it is of interest as a potential scaffold for drug development. Drugs based on kaitocephalin may be useful in treating neurological conditions, including Alzheimer's, amyotrophic lateral sclerosis (ALS), and stroke.
"}{"type":"standard","title":"Ending Is Beginning","displaytitle":"Ending Is Beginning","namespace":{"id":0,"text":""},"wikibase_item":"Q5376145","titles":{"canonical":"Ending_Is_Beginning","normalized":"Ending Is Beginning","display":"Ending Is Beginning"},"pageid":17682959,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/a/aa/EIB_cover.jpg","width":250,"height":250},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/a/aa/EIB_cover.jpg","width":250,"height":250},"lang":"en","dir":"ltr","revision":"1222620833","tid":"979f2c5b-0c03-11ef-91dc-5d23cf258187","timestamp":"2024-05-06T23:51:44Z","description":"2008 studio album by Downhere","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Ending_Is_Beginning","revisions":"https://en.wikipedia.org/wiki/Ending_Is_Beginning?action=history","edit":"https://en.wikipedia.org/wiki/Ending_Is_Beginning?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Ending_Is_Beginning"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Ending_Is_Beginning","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Ending_Is_Beginning","edit":"https://en.m.wikipedia.org/wiki/Ending_Is_Beginning?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Ending_Is_Beginning"}},"extract":"Ending Is Beginning is the fifth official album release from Christian rock band Downhere. It was released on September 23, 2008. In May 2008, fans played a part in selecting the songs chosen for this album by rating and scoring 17 potential songs on audioscorecard.com.","extract_html":"
Ending Is Beginning is the fifth official album release from Christian rock band Downhere. It was released on September 23, 2008. In May 2008, fans played a part in selecting the songs chosen for this album by rating and scoring 17 potential songs on audioscorecard.com.
"}{"type":"standard","title":"Paliseul","displaytitle":"Paliseul","namespace":{"id":0,"text":""},"wikibase_item":"Q696127","titles":{"canonical":"Paliseul","normalized":"Paliseul","display":"Paliseul"},"pageid":176215,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/6/62/Paliseul_JPG001.jpg/330px-Paliseul_JPG001.jpg","width":320,"height":240},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/6/62/Paliseul_JPG001.jpg","width":2272,"height":1704},"lang":"en","dir":"ltr","revision":"1279458086","tid":"20358e06-fc48-11ef-94ba-75a3bae3ecb9","timestamp":"2025-03-08T18:06:58Z","description":"Municipality in Luxembourg Province, Belgium","description_source":"local","coordinates":{"lat":49.9,"lon":5.13333333},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Paliseul","revisions":"https://en.wikipedia.org/wiki/Paliseul?action=history","edit":"https://en.wikipedia.org/wiki/Paliseul?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Paliseul"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Paliseul","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Paliseul","edit":"https://en.m.wikipedia.org/wiki/Paliseul?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Paliseul"}},"extract":"Paliseul is a municipality of Wallonia located in the province of Luxembourg, Belgium.","extract_html":"
Paliseul is a municipality of Wallonia located in the province of Luxembourg, Belgium.
"}{"type":"standard","title":"Ocosce","displaytitle":"Ocosce","namespace":{"id":0,"text":""},"wikibase_item":"Q7076634","titles":{"canonical":"Ocosce","normalized":"Ocosce","display":"Ocosce"},"pageid":24225181,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/c4/OcosceCascia3.jpg/330px-OcosceCascia3.jpg","width":320,"height":214},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/c/c4/OcosceCascia3.jpg","width":4028,"height":2688},"lang":"en","dir":"ltr","revision":"1294286869","tid":"14c0360f-4315-11f0-8172-9578bb81f700","timestamp":"2025-06-06T20:30:27Z","description":"Frazione in Umbria, Italy","description_source":"local","coordinates":{"lat":42.71583333,"lon":12.99888889},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Ocosce","revisions":"https://en.wikipedia.org/wiki/Ocosce?action=history","edit":"https://en.wikipedia.org/wiki/Ocosce?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Ocosce"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Ocosce","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Ocosce","edit":"https://en.m.wikipedia.org/wiki/Ocosce?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Ocosce"}},"extract":"Ocosce is a frazione of the comune of Cascia in the Province of Perugia, Umbria, central Italy. It stands at an elevation of 911 metres above sea level. At the time of the Istat census of 2001 it had 93 inhabitants.","extract_html":"
Ocosce is a frazione of the comune of Cascia in the Province of Perugia, Umbria, central Italy. It stands at an elevation of 911 metres above sea level. At the time of the Istat census of 2001 it had 93 inhabitants.
"}